CZC 25146

Name: CZC 25146
Brand: Tocris Bioscience
SKU: 6071

Tocris Bioscience, part of Bio-Techne | Catalog # 6071

Citations (6)

COA / SDS

Potent LRRK2 inhibitor

Key Product Details

Description:	Potent LRRK2 inhibitor
Chemical Name:	N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	488.54

View Full Technical Details for CZC 25146

Technical Data
Citations

Biological Activity for CZC 25146

CZC 25146 is a potent LRRK2 inhibitor (IC₅₀ values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Compound Libraries for CZC 25146

CZC 25146 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CZC 25146

M. Wt	488.54
Formula	C₂₂H₂₅FN₆O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1191911-26-8
PubChem ID	44252884
InChi Key	XXHHOTZUJIXPJX-UHFFFAOYSA-N
Smiles	FC1=C(NC2=CC=CC=C2NS(C)(=O)=O)N=C(NC3=C(OC)C=C(N4CCOCC4)C=C3)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CZC 25146

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.85	100

Preparing Stock Solutions for CZC 25146

The following data is based on the product molecular weight 488.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for CZC 25146

References are publications that support the biological activity of the product.

Ramsden Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem.Biol. 2011 PMID: 21812418