Cytosporone B
Tocris Bioscience, part of Bio-Techne | Catalog # 5459
High affinity Nur77 agonist
Key Product Details
Description
High affinity Nur77 agonist
Product Description
Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.Product Specifications
Molecular Weight
322.40
Formula
C18H26O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
CAS Number
321661-62-5
PubChem ID
10687292
InChI Key
UVVWQQKSNZLUQA-UHFFFAOYSA-N
SMILES
OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.24 | 100 | |
| Ethanol | 32.24 | 100 |
Preparing Stock Solutions
for Cytosporone B
The following data is based on the product molecular weight 322.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.20 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhan Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 2008 PMID: 18690216
- Palumbo-Zerr Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 2015 PMID: 25581517
Product Specific Notices for Cytosporone B
For research use only
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