Cystamine dihydrochloride

Name: Cystamine dihydrochloride
Brand: Tocris Bioscience
SKU: 4981

Tocris Bioscience, part of Bio-Techne | Catalog # 4981

COA / SDS

Transglutaminase inhibitor; neuroprotective

Discontinued Product

4981 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description:	Transglutaminase inhibitor; neuroprotective
Chemical Name:	2,2'-Diaminodiethyl disulfide dihydrochloride
Molecular Weight:	225.2

View Full Technical Details for Cystamine dihydrochloride

Technical Data
Citations

Biological Activity for Cystamine dihydrochloride

Cystamine dihydrochloride is a transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

Technical Data for Cystamine dihydrochloride

M. Wt	225.2
Formula	C₄H₁₂N₂S₂.2HCl
Storage	Desiccate at RT
CAS Number	56-17-7
PubChem ID	5941
InChi Key	YUFRRMZSSPQMOS-UHFFFAOYSA-N
Smiles	NCCSSCCN.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Cystamine dihydrochloride

References are publications that support the biological activity of the product.

Dedeoglu Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 2002 PMID: 12388601
Mao Cystamine and cyste. prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 2006 PMID: 16623826
Borrell-Pages Cystamine and cyste. increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 2006 PMID: 16604191

Cystamine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4981

Key Product Details

Biological Activity for Cystamine dihydrochloride

Technical Data for Cystamine dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Cystamine dihydrochloride

Product Documents for Cystamine dihydrochloride

COA

Certificate of Analysis

SDS

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