3-Nitropropionic acid

Name: 3-Nitropropionic acid
Brand: Tocris Bioscience
SKU: 4849

Tocris Bioscience, part of Bio-Techne | Catalog # 4849

COA / SDS

Irreversible mitochondrial respiratory complex II inhibitor

Discontinued Product

4849 has been discontinued. View all Oxidative Phosphorylation Inhibitors products.

Key Product Details

Description:	Irreversible mitochondrial respiratory complex II inhibitor
Purity:	≥97% (HPLC)
Molecular Weight:	119.08

View Full Technical Details for 3-Nitropropionic acid

Technical Data
Citations

Biological Activity for 3-Nitropropionic acid

3-Nitropropionic acid is an irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Technical Data for 3-Nitropropionic acid

M. Wt	119.08
Formula	C₃H₅NO₄
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	504-88-1
PubChem ID	1678
InChi Key	WBLZUCOIBUDNBV-UHFFFAOYSA-N
Smiles	OC(CC[N+]([O-])=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 3-Nitropropionic acid

References are publications that support the biological activity of the product.

Solesio 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 2013 PMID: 22509855
Huang 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 2005 PMID: 16371358
de Oca Balderas Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. 2013 PMID: 23643981

3-Nitropropionic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 4849

Key Product Details

Biological Activity for 3-Nitropropionic acid

Technical Data for 3-Nitropropionic acid

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 3-Nitropropionic acid

Product Documents for 3-Nitropropionic acid

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected