Cyprodime hydrochloride

Name: Cyprodime hydrochloride
Brand: Tocris Bioscience
SKU: 2601
Rating: 5 (0 reviews)

Catalog # 2601 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Selective μ antagonist

Key Product Details

Description:	Selective μ antagonist
Chemical Name:	17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	391.93

View Full Technical Details for Cyprodime hydrochloride

Technical Data
Citations (2) / Reviews

Biological Activity for Cyprodime hydrochloride

Cyprodime hydrochloride is a selective μ-opioid receptor antagonist (K_i values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Technical Data for Cyprodime hydrochloride

M. Wt	391.93
Formula	C₂₂H₂₉NO₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	2387505-50-0
PubChem ID	71628324
InChi Key	MMOBYZBXXHEAAX-NCBCLDNOSA-N
Smiles	O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyprodime hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.19	100
	ethanol	39.19	100

Preparing Stock Solutions for Cyprodime hydrochloride

The following data is based on the product molecular weight 391.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.76 mL	25.51 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for Cyprodime hydrochloride

References are publications that support the biological activity of the product.

Henry μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 2001 PMID: 11520128
Marki μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [³⁵S]GTPγs binding assays. Eur.J.Pharmacol. 1999 PMID: 10585536
Schmidhammer Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 1995 PMID: 7636870

Citations for Cyprodime hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Cyprodime hydrochloride include:

Norris et al. (2019) The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions. Sci Rep. 9:9760
PMID: 31278333
Lee et al. (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Neurosci. 2012:941685
PMID: 22645476

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Customer Reviews for Cyprodime hydrochloride (1)

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Opioid Receptor Antagonist

Name: Steven Laviolette

Assay Type: In Vivo

Intra-cranial microinfusions for behavioural testing.

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