CYM 5541
Tocris Bioscience, part of Bio-Techne | Catalog # 4897
Selective S1P3 receptor allosteric agonist
Key Product Details
Description
Selective S1P3 receptor allosteric agonist
Product Description
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.Product Specifications
Molecular Weight
316.44
Formula
C19H28N2O2
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
CAS Number
945128-26-7
PubChem ID
17253208
InChI Key
NDKGACIWVAOUQH-UHFFFAOYSA-N
SMILES
O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 | |
| Ethanol | 15.82 | 50 |
Preparing Stock Solutions
for CYM 5541
The following data is based on the product molecular weight 316.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.80 mL | 31.60 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jo Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 2012 PMID: 22971058
Product Specific Notices for CYM 5541
For research use only
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