CYM 5442 hydrochloride

Name: CYM 5442 hydrochloride
Brand: Tocris Bioscience
SKU: 3601

Tocris Bioscience, part of Bio-Techne | Catalog # 3601

Citations (6)

COA / SDS

Selective S1P1 receptor agonist

Key Product Details

Description:	Selective S1P₁ receptor agonist
Chemical Name:	2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	445.94

View Full Technical Details for CYM 5442 hydrochloride

Technical Data
Citations

Biological Activity for CYM 5442 hydrochloride

CYM 5442 hydrochloride is a potent and selective S1P₁ agonist in vitro (EC₅₀ = 1.35 nM). Activates S1P₁-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P₁. Induces acute lymphopenia in mice. Brain penetrant.

Compound Libraries for CYM 5442 hydrochloride

CYM 5442 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 5442 hydrochloride

M. Wt	445.94
Formula	C₂₃H₂₇N₃O₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1783987-80-3
PubChem ID	90488865
InChi Key	KMZLVDAVGXYZDA-UHFFFAOYSA-N
Smiles	OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CYM 5442 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.59	100

Preparing Stock Solutions for CYM 5442 hydrochloride

The following data is based on the product molecular weight 445.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for CYM 5442 hydrochloride

References are publications that support the biological activity of the product.

Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 2008 PMID: 18708635