CYM 50358 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4679
Potent and selective S1P4 antagonist
Key Product Details
Description
Potent and selective S1P4 antagonist
Product Description
CYM 50358 hydrochloride is a potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.Product Specifications
Molecular Weight
425.74
Formula
C20H18Cl2N2O2.HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
CAS Number
1781750-72-8
PubChem ID
78243726
InChI Key
OFDSTJOMVDAKCS-UHFFFAOYSA-N
SMILES
O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 42.57 | 100 | |
| DMSO | 42.57 | 100 |
Preparing Stock Solutions
for CYM 50358 hydrochloride
The following data is based on the product molecular weight 425.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.74 mL | 23.49 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.70 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cencetti TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 2013 PMID: 23913862
- Guerrero Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 2011 PMID: 21570287
Product Specific Notices for CYM 50358 hydrochloride
For research use only
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