CYM 50308
Tocris Bioscience, part of Bio-Techne | Catalog # 4678
Potent and selective S1P4 agonist
Key Product Details
Description
Potent and selective S1P4 agonist
Product Description
CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Displays no activity at S1P1, S1P2 and S1P3 receptors at concentrations up to 25 μM.Product Specifications
Molecular Weight
405.46
Formula
C20H21F2N3O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone
CAS Number
1345858-76-5
PubChem ID
49835928
InChI Key
BKQZKTRCUAWRHT-ONBPWHQPSA-N
SMILES
FC1=CC(F)=C(N2C(C)=CC(/C=C3\S/C(N(C)C3=O)=N\CCOC)=C2C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.05 | 10 |
Preparing Stock Solutions
for CYM 50308
The following data is based on the product molecular weight 405.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.66 mL | 123.32 mL | 246.63 mL |
| 0.5 mM | 4.93 mL | 24.66 mL | 49.33 mL |
| 1 mM | 2.47 mL | 12.33 mL | 24.66 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Urbano Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 2011 PMID: 21982495
Product Specific Notices for CYM 50308
For research use only
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