Cyclotraxin B

Name: Cyclotraxin B
Brand: Tocris Bioscience
SKU: 5062

Tocris Bioscience, part of Bio-Techne | Catalog # 5062

Citations (17)

COA / SDS

TrkB receptor antagonist

Key Product Details

Description:	TrkB receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1200.36

View Full Technical Details for Cyclotraxin B

Technical Data
Citations

Biological Activity for Cyclotraxin B

Cyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC₅₀ = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Technical Data for Cyclotraxin B

M. Wt	1200.36
Formula	C₄₈H₇₃N₁₃O₁₇S₃
Single Letter Sequence	CNPMGYTKEGC (Modification: Disulfide bridge: 1-11)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1203586-72-4
PubChem ID	90489002
InChi Key	JLBMMJHZUYBFGX-ZHTCEXBHSA-N
Smiles	[H]N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclotraxin B

Solubility

Soluble to 2mg/ml in water

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References for Cyclotraxin B

References are publications that support the biological activity of the product.

Cazorla Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 2010 PMID: 20333308
Constandil Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 2012 PMID: 22560237