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Cyclopiazonic acid

Tocris Bioscience a Bio-Techne Brand

Cyclopiazonic acid | CAS No. 18172-33-3 | Inhibitor of SERCA ATPase
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Key Product Details

Description: Inhibitor of SERCA ATPase
Alternative Names: α-Cyclopiazonic acid
Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
Purity: ≥98% (HPLC)
Molecular Weight: 336.39

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Citations for Cyclopiazonic acid (15)

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Customer Reviews for Cyclopiazonic acid (2)

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  • Cyclopiazonic Acid Blocks Re-Uptake of Ca2+ Into ER leading to increased T-cell activation by IFNg
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Primary Cd8+ T-cells
    Cyclopiazonic acid (CPA) was used to block SERCA in activated CD8+ T-cells. This maintained high intracellular Ca2+, leading to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.
    Cyclopiazonic acid Serum 1235
  • Cyclopiazonic acid (CPA) depletes ER Ca2+ stores, leading to STIM1 clustering in in HEK293 cells.
    Name: Niroj Shrestha
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    ER resident protein, STIM1 was expressed with YFP fluorescent tag in HEK293 cells and imaged using TIRF microscopy. STIM1 (left) clusters to form punctae at PM-ER junctions upon ER Ca2+ store depletion (right) by CPA (25 µM in DMSO), thereby activating Orai1-mediated Ca2+ entry.
    Cyclopiazonic acid Serum 1235

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Product Documents for Cyclopiazonic acid

Certificate of Analysis

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