CX-4945

Name: CX-4945
Brand: Tocris Bioscience
SKU: 8993

Tocris Bioscience, part of Bio-Techne | Catalog # 8993

COA / SDS

Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming

Key Product Details

Description:	Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming
Alternative Names:	Silmitasertib
Chemical Name:	Sodium 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	371.76

View Full Technical Details for CX-4945

Technical Data
Citations

Biological Activity for CX-4945

CX-4945 (Silmitasertib) is a potent and selective inhibitor of protein kinase CK2α and CK2α' (IC₅₀ = 1 nM). It shows greater than 500-fold selectivity for CK2 over a panel of > 200 kinases.

CX-4945 can be used, in combination with other small molecules, in fast chemical reprogramming protocols for the induction of human somatic cells and highly efficient generation of pluripotent stem cells (hCiPS) in a minimum of 16 days with robust repeatability and reliability.

CX-4945 has antiproliferative effects in vitro as it attenuates PI3K/Akt signalling, causes cell-cycle arrest and selectively induces apoptosis in cancer cells. In models of angiogenesis, CX-4945 inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

In vivo, CX-4945 displays robust antitumor activity with concomitant reduction of the mechanism-based biomarker phospho-p21 (T145) (murine xenograft model). CX-4945 is orally bioavailable.

Technical Data for CX-4945

M. Wt	371.76
Formula	C₁₉H₁₁ClN₃O₂Na
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1309357-15-0
PubChem ID	49788959
InChi Key	ODDAAPQSODILSN-UHFFFAOYSA-M
Smiles	O=C(C1=CC(N=C(C2=C3C=NC=C2)NC4=CC(Cl)=CC=C4)=C3C=C1)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CX-4945

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.18	100
	DMSO	37.18	100

Preparing Stock Solutions for CX-4945

The following data is based on the product molecular weight 371.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.90 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CX-4945

References are publications that support the biological activity of the product.

Liuyang Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. Cell Stem Cell 2023 PMID: 36944335
Wang A rapid chemical reprogramming system to generate human pluripotent stem cells. Nat.Chem.Biol. 2025 PMID: 39753706
Siddiqui-Jain CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 PMID: 21159648