CVT 313

Name: CVT 313
Brand: Tocris Bioscience
SKU: 6174

Tocris Bioscience, part of Bio-Techne | Catalog # 6174

Citations (2)

COA / SDS

Cdk2 and cdk5 inhibitor

Key Product Details

Description:	Cdk2 and cdk5 inhibitor
Chemical Name:	2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity:	≥98% (HPLC)
Molecular Weight:	400.47

View Full Technical Details for CVT 313

Technical Data
Citations

Biological Activity for CVT 313

CVT 313 is a cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC₅₀ values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC₅₀ = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.

Compound Libraries for CVT 313

CVT 313 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CVT 313

M. Wt	400.47
Formula	C₂₀H₂₈N₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	199986-75-9
PubChem ID	6918386
InChi Key	NQVIIUBWMBHLOZ-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)CNC2=NC(N(CCO)CCO)=NC3=C2N=CN3C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CVT 313

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.05	100
	ethanol	40.05	100

Preparing Stock Solutions for CVT 313

The following data is based on the product molecular weight 400.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for CVT 313

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Brooks CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J.Biol.Chem. 1997 PMID: 9360999