CVT 10216
Tocris Bioscience, part of Bio-Techne | Catalog # 5164
Potent and selective ALDH2 inhibitor
Key Product Details
Description
Potent and selective ALDH2 inhibitor
Product Description
CVT 10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.Product Specifications
Molecular Weight
465.48
Formula
C24H19NO7S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
CAS Number
1005334-57-5
PubChem ID
23661666
InChI Key
YYOOFJZTRCPVFD-UHFFFAOYSA-N
SMILES
O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.55 | 100 | |
| 1eq. NaOH | 23.27 | 50 |
Preparing Stock Solutions
for CVT 10216
The following data is based on the product molecular weight 465.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.30 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yao Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of DA synthesis. Nat.Med. 2010 PMID: 20729865
- Overstreet A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 2009 PMID: 19747934
Product Specific Notices for CVT 10216
For research use only
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