Curcumin

Name: Curcumin
Brand: Tocris Bioscience
SKU: 2841
Rating: 5 (0 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2841

Citations (5)

(1)

COA / SDS

Discontinued Product

2841 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	Antitumor, anti-inflammatory and antioxidant
Alternative Names:	Diferuloylmethane
Chemical Name:	(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Molecular Weight:	368.38

View Full Technical Details for Curcumin

Biological Activity for Curcumin

Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data for Curcumin

M. Wt	368.38
Formula	C₂₁H₂₀O₆
Storage	Store at -20°C
CAS Number	458-37-7
PubChem ID	969516
InChi Key	VFLDPWHFBUODDF-FCXRPNKRSA-N
Smiles	O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Curcumin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.68	10
	ethanol	1.84	5

Preparing Stock Solutions for Curcumin

The following data is based on the product molecular weight 368.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.15 mL	135.73 mL	271.46 mL
0.5 mM	5.43 mL	27.15 mL	54.29 mL
1 mM	2.71 mL	13.57 mL	27.15 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

Molarity Calculator

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Reconstitution Calculator

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References for Curcumin

References are publications that support the biological activity of the product.

Aggarwal and Sung Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 2009 PMID: 19110321
Kuttan Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569210
Cole Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569212
Lin Molecular targets of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569214
Miriyala Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 2007 PMID: 17569220

Citations for Curcumin (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Curcumin include:

Boija et al. (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell. 68:491
PMID: 29056321
Efthymiou et al. (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci. 4:230
PMID: 25637190
Chang et al. (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 5:10256
PMID: 26194093
Chen et al. (2012) Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med. 30:1021
PMID: 22922731
Han et al. (2012) Analgesic effects of intrathecal curcumin in the rat formalin test. Korean J Pain. 25:43252
PMID: 22259709

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Customer Reviews for Curcumin (1)

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Curcumin treatment of mouse macrophages

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: macrophage

used at 10um to activate anti-oxidant response in mouse macrophages

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