CU-T12-9
Tocris Bioscience, part of Bio-Techne | Catalog # 5414
Potent TLR1/2 agonist
Product Description
CU-T12-9 is a potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.Licensing Information
Sold under license from the University of ColoradoProduct Specifications
Molecular Weight
362.31
Formula
C17H13F3N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
CAS Number
1821387-73-8
PubChem ID
91826088
InChI Key
LITXVDAFEYLWQE-UHFFFAOYSA-N
SMILES
CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.23 | 100 | |
| Ethanol | 7.25 | 20 |
Preparing Stock Solutions
for CU-T12-9
The following data is based on the product molecular weight 362.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.80 mL | 27.60 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 2015 PMID: 26101787
- Cheng Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 2013 PMID: 22969053
Product Specific Notices for CU-T12-9
For research use only
Loading...
Loading...
Loading...