CU CPT 4a

Name: CU CPT 4a
Brand: Tocris Bioscience
SKU: 4883

Tocris Bioscience, part of Bio-Techne | Catalog # 4883

Citations (14)

COA / SDS

Selective TLR3 inhibitor

Key Product Details

Description:	Selective TLR3 inhibitor
Chemical Name:	N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
Purity:	≥98% (HPLC)
Molecular Weight:	377.82

View Full Technical Details for CU CPT 4a

Technical Data
Citations

Biological Activity for CU CPT 4a

CU CPT 4a is a selective TLR3 inhibitor (IC₅₀ = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU CPT 4a

CU CPT 4a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU CPT 4a

M. Wt	377.82
Formula	C₁₈H₁₃ClFNO₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1279713-77-7
PubChem ID	53242268
InChi Key	IAASQMCXDRISAV-CYBMUJFWSA-N
Smiles	O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU CPT 4a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.78	100

Preparing Stock Solutions for CU CPT 4a

The following data is based on the product molecular weight 377.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.47 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for CU CPT 4a

References are publications that support the biological activity of the product.

Takemura Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 2014 PMID: 24637670
Cheng Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 2011 PMID: 21355588