CU CPT 4a
Tocris Bioscience, part of Bio-Techne | Catalog # 4883
Selective TLR3 inhibitor
Product Description
CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.Licensing Information
Sold under license from the University of ColoradoProduct Specifications
Molecular Weight
377.82
Formula
C18H13ClFNO3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
CAS Number
1279713-77-7
PubChem ID
53242268
InChI Key
IAASQMCXDRISAV-CYBMUJFWSA-N
SMILES
O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.78 | 100 |
Preparing Stock Solutions
for CU CPT 4a
The following data is based on the product molecular weight 377.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.23 mL | 26.47 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.29 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Takemura Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 2014 PMID: 24637670
- Cheng Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 2011 PMID: 21355588
Product Specific Notices for CU CPT 4a
For research use only
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