CU CPT 22

Name: CU CPT 22
Brand: Tocris Bioscience
SKU: 4884

Tocris Bioscience a Bio-Techne Brand

Catalog # 4884

Citations (2)

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Key Product Details

Description:	Selective TLR1/2 inhibitor
Chemical Name:	3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	362.37

View Full Technical Details for CU CPT 22

Biological Activity for CU CPT 22

CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC₅₀ = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Licensing Information

Sold under license from the University of Colorado

Technical Data for CU CPT 22

M. Wt	362.37
Formula	C₁₉H₂₂O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1416324-85-0
PubChem ID	71503400
InChi Key	UBQFTTUFRSSOHE-UHFFFAOYSA-N
Smiles	O=C1C(O)=CC(C(OCCCCCC)=O)=CC2=C1C(O)=C(O)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU CPT 22

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.24	100

Preparing Stock Solutions for CU CPT 22

The following data is based on the product molecular weight 362.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.60 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for CU CPT 22

References are publications that support the biological activity of the product.

Cheng Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 2012 PMID: 22969053

Citations for CU CPT 22 (2)

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Citations are publications that use Bio-Techne products. Selected citations for CU CPT 22 include:

Ahn et al. (2019) Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 43:291
PMID: 30976167
Ghonime et al. (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res. 10:e0127278
PMID: 25993107

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Product Documents for CU CPT 22

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.