CTOP

Tocris Bioscience, part of Bio-Techne | Catalog # 1578

Citations (69)

COA / SDS

Potent and selective μ antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective μ antagonist

View all mu Opioid Receptor Antagonists »

Product Description

CTOP is a potent and selective μ opioid receptor antagonist (K_i values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K⁺ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.

Product Specifications

Molecular Weight

1062.28

Formula

C₅₀H₆₇N₁₁O₁₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

103429-31-8

PubChem ID

90479805

InChI Key

PZWWYAHWHHNCHO-KOFBULAQSA-N

SMILES

[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Chieng The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a no Mol.Pharmacol. 1996 PMID: 8794906
Gulya Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH² (CTOP) in mice. Eur.J.Pharmacol. 1988 PMID: 2901358
Hawkins [³H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH₂] ([³H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain. J.Pharmacol.Exp.Ther. 1989 PMID: 2563293
Badiani Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Brain Res. 1995 PMID: 7496796