CTAP

Tocris Bioscience, part of Bio-Techne | Catalog # 1560

Citations (78)

COA / SDS

Potent and selective μ antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective μ antagonist

View all mu Opioid Receptor Antagonists »

Product Description

CTAP is a potent and selective μ opioid receptor antagonist (IC₅₀ = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo.

Product Specifications

Molecular Weight

1104.32

Formula

C₅₁H₆₉N₁₃O₁₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

103429-32-9

PubChem ID

90479802

InChI Key

OFMQLVRLOGHAJI-KOFBULAQSA-N

SMILES

[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Kramer Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo. J.Pharmacol.Exp.Ther. 1989 PMID: 2566679
Pelton Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J.Med.Chem. 1986 PMID: 2878079
Abbruscato Blood-brain barrier permeability and bioavailability of a highly potent and μ-selective opioid receptor antagonist, CTAP: comparison with mor. J.Pharmacol.Exp.Ther. 1997 PMID: 8996221