CTA 056

Name: CTA 056
Brand: Tocris Bioscience
SKU: 4726
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4726

(1)

Citations (1)

COA / SDS

ITK inhibitor

Key Product Details

Description:	ITK inhibitor
Chemical Name:	1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	554.68

View Full Technical Details for CTA 056

Technical Data
Citations / Reviews (1)

Biological Activity for CTA 056

CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC₅₀ values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Technical Data for CTA 056

M. Wt	554.68
Formula	C₃₅H₃₄N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1265822-30-7
PubChem ID	49870925
InChi Key	BSSBAJKNZOHHCA-UHFFFAOYSA-N
Smiles	O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CTA 056

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.55	10 with gentle warming

Preparing Stock Solutions for CTA 056

The following data is based on the product molecular weight 554.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.03 mL	90.14 mL	180.28 mL
0.5 mM	3.61 mL	18.03 mL	36.06 mL
1 mM	1.80 mL	9.01 mL	18.03 mL
5 mM	0.36 mL	1.80 mL	3.61 mL

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References for CTA 056

References are publications that support the biological activity of the product.

Guo Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 2012 PMID: 22899868