CS 640
Tocris Bioscience, part of Bio-Techne | Catalog # 7982
Potent CaM kinase I inhibitor
Product Description
CS 640 is a potent calmodulin-dependent kinase I (CaMKI) inhibitor (IC50 values are 1 nM, 1 nM, 3 nM and 8 nM at CAMK1A, CAMK1G, CAMK1B and CAMK1D respectively). Improves insulin sensitivity and glucose control in a mouse model of diet-induced obesity. Orally bioavailable in rodents.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the CS 640 probe summary on the SGC website.Product Specifications
Molecular Weight
397.53
Formula
C21H31N7O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide
CAS Number
2388506-83-8
PubChem ID
145946080
InChI Key
BWBUPDTUXQDHSX-AWEZNQCLSA-N
SMILES
NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.95 | 20 | |
| Ethanol | 3.98 | 10 |
Preparing Stock Solutions
for CS 640
The following data is based on the product molecular weight 397.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.58 mL | 62.89 mL | 125.78 mL |
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 2 mM | 1.26 mL | 6.29 mL | 12.58 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fromont Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obesity in vivo mouse model. J.Med.Chem. 2020 PMID: 32433887
Product Specific Notices for CS 640
For research use only
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