CS 2100
Tocris Bioscience, part of Bio-Techne | Catalog # 4543
Selective S1P1 agonist
Key Product Details
Description
Selective S1P1 agonist
Product Description
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.Product Specifications
Molecular Weight
461.53
Formula
C25H23N3O4S
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
CAS Number
913827-99-3
PubChem ID
11977938
InChI Key
DWVJASHDNJMDNH-UHFFFAOYSA-N
SMILES
CCC1=C(C2=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)SC(CN3CC(C(O)=O)C3)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.31 | 5 with gentle warming |
Preparing Stock Solutions
for CS 2100
The following data is based on the product molecular weight 461.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 43.33 mL | 216.67 mL | 433.34 mL |
| 0.25 mM | 8.67 mL | 43.33 mL | 86.67 mL |
| 0.5 mM | 4.33 mL | 21.67 mL | 43.33 mL |
| 2.5 mM | 0.87 mL | 4.33 mL | 8.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nakamura Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg.Med.Chem.Lett. 2012 PMID: 22264485
- Nakamura Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Eur.J.Med.Chem. 2012 PMID: 22405291
Product Specific Notices for CS 2100
For research use only
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