CRT 0066854 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5922
PKCι and PKCζ inhibitor
Product Description
CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.Product Specifications
Molecular Weight
488.48
Formula
C24H25N5S.2HCl
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride
CAS Number
2250019-91-9
PubChem ID
131954580
InChI Key
NYUVOWXZRBZQBA-NTEVMMBTSA-N
SMILES
N[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(SC3=NC(C5=CC=NC=C5)=N2)CCCC4.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 48.85 | 100 | |
| DMSO | 48.85 | 100 |
Preparing Stock Solutions
for CRT 0066854 hydrochloride
The following data is based on the product molecular weight 488.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.24 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kjaer Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem.J. 2013 PMID: 23418854
- Linch Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 2014 PMID: 24072773
Product Specific Notices for CRT 0066854 hydrochloride
For research use only
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