CRBN5-SNAP2-1C-PIP

Name: CRBN5-SNAP2-1C-PIP
Brand: Tocris Bioscience
SKU: 8891

Tocris Bioscience, part of Bio-Techne | Catalog # 8891

COA / SDS

Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins

Key Product Details

Description:	Degrader (PROTAC^®) of SNAP-tag™ labeled fusion proteins
Chemical Name:	N-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetamide
Purity:	≥97% (HPLC)
Molecular Weight:	646.1

View Full Technical Details for CRBN5-SNAP2-1C-PIP

Technical Data
Citations

Biological Activity for CRBN5-SNAP2-1C-PIP

CRBN5-SNAP2-1C-PIP is a Degrader (PROTAC^®) of SNAP-tag™ labeled fusion proteins (D_max = 75% at 1 μM). CRBN5-SNAP2-1C-PIP recruits cereblon E3 ligase to induce the degradation of SNAP-fusion proteins.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

SNAP-tag is a trademark of New England BioLabs, Inc.

Technical Data for CRBN5-SNAP2-1C-PIP

M. Wt	646.1
Formula	C₃₂H₃₂ClN₇O₆
Storage	Store at -20°C
Purity	≥97% (HPLC)
InChi Key	HZTNPAVHBCQKFV-UHFFFAOYSA-N
Smiles	O=C(NCC1=CC=C(COC2=NC(N)=NC(Cl)=C2)C=C1)CC3CCN(C4=CC=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=C4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CRBN5-SNAP2-1C-PIP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	64.61	100

Preparing Stock Solutions for CRBN5-SNAP2-1C-PIP

The following data is based on the product molecular weight 646.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.55 mL	7.74 mL	15.48 mL
5 mM	0.31 mL	1.55 mL	3.10 mL
10 mM	0.15 mL	0.77 mL	1.55 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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References for CRBN5-SNAP2-1C-PIP

References are publications that support the biological activity of the product.

Pol Induced degradation of SNAP-fusion proteins. RSC Chem.Biol. 2024 PMID: 39444693