CRBN PROTAC® 14a
Tocris Bioscience, part of Bio-Techne | Catalog # 7219
Cereblon Degrader (PROTAC®)
Product Description
CRBN PROTAC® 14a is a cereblon Degrader (PROTAC®). Comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. Preferentially degrades cereblon (DC50 = 200 nM in HEK293 cells). Induces rapid and profound cereblon degradation (98% decrease after 8 h at 1 μM in HEK293 cells).CRBN antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP1-91810.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under licence from the University of DundeeProduct Specifications
Molecular Weight
1061.26
Formula
C53H72N8O13S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
CAS Number
2358775-70-7
PubChem ID
138911387
InChI Key
PEZCAXDTKNFUCR-CTMFSBKBSA-N
SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCCCCOCCOCCCCCOCC(NCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)=O)=O)O)=O)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 106.13 | 100 |
Preparing Stock Solutions
for CRBN PROTAC® 14a
The following data is based on the product molecular weight 1061.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.94 mL | 4.71 mL | 9.42 mL |
| 5 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 10 mM | 0.09 mL | 0.47 mL | 0.94 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Girardini Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg.Med.Chem. 2019 PMID: 30826187
Product Specific Notices for CRBN PROTAC® 14a
For research use only
Loading...
Loading...