CPS2
Tocris Bioscience, part of Bio-Techne | Catalog # 7800
Potent and selective CDK2 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective CDK2 Degrader (PROTAC®)
Product Description
CPS2 is a potent and selective CDK2 Degrader (PROTAC®) (IC50 = 24 nM). It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. It induces differentiation of AML cell lines, primary AML cells, and granulocytic differentiation of HSCs.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
890.95
Formula
C38H42N12O10S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide
CAS Number
2756741-90-7
PubChem ID
155294157
InChI Key
BXCPYBFBMAWDDY-UHFFFAOYSA-N
SMILES
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCN4N=NC(COCCNS(=O)(C5=CC=C(NC6=NN(C(C7=C(C)C=CS7)=O)C(N)=N6)C=C5)=O)=C4)=CC=C3)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 89.09 | 100 |
Preparing Stock Solutions
for CPS2
The following data is based on the product molecular weight 890.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.12 mL | 5.61 mL | 11.22 mL |
| 5 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 10 mM | 0.11 mL | 0.56 mL | 1.12 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol. 2021 PMID: 33664520
Product Specific Notices for CPS2
For research use only
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