CP 945598 hydrochloride

Name: CP 945598 hydrochloride
Brand: Tocris Bioscience
SKU: 4236

Tocris Bioscience, part of Bio-Techne | Catalog # 4236

Citations (3)

COA / SDS

CB1 antagonist

Key Product Details

Description:	CB₁ antagonist
Chemical Name:	1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	546.88

View Full Technical Details for CP 945598 hydrochloride

Technical Data
Citations

Biological Activity for CP 945598 hydrochloride

CP 945598 hydrochloride is a selective, high affinity CB₁ antagonist (K_i values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB₂ receptors (K_i = 7600 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 945598 hydrochloride

M. Wt	546.88
Formula	C₂₅H₂₅Cl₂N₇O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	686347-12-6
PubChem ID	16223963
InChi Key	KPYUQCJBZGQHPL-UHFFFAOYSA-N
Smiles	CCNC(CC4)(C(N)=O)CCN4C1=NC=NC2=C1N=C(C5=C(Cl)C=CC=C5)N2C3=CC=C(Cl)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 945598 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.94	20

Preparing Stock Solutions for CP 945598 hydrochloride

The following data is based on the product molecular weight 546.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.71 mL	91.43 mL
1 mM	1.83 mL	9.14 mL	18.29 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

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References for CP 945598 hydrochloride

References are publications that support the biological activity of the product.

Hadcock In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB₁ receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 2010 PMID: 20211605
Griffith Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 2009 PMID: 19102698