CP 93129 dihydrochloride

Name: CP 93129 dihydrochloride
Brand: Tocris Bioscience
SKU: 1032
Rating: 4 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1032

Citations (9)

(2)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	5-HT_1B agonist
Chemical Name:	1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Molecular Weight:	288.18

View Full Technical Details for CP 93129 dihydrochloride

Biological Activity for CP 93129 dihydrochloride

CP 93129 dihydrochloride is a potent and highly selective 5-HT_1B agonist (K_i values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT_1B, 5-HT_1D, 5-HT_1A, 5-HT_1c and 5-HT₂, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 93129 dihydrochloride

M. Wt	288.18
Formula	C₁₂H₁₃N₃O.2HCl
Storage	Desiccate at RT
CAS Number	879089-64-2
PubChem ID	46927988
InChi Key	FLVJHUZZKVJQNH-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 93129 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.82	100
	water	28.82	100

Preparing Stock Solutions for CP 93129 dihydrochloride

The following data is based on the product molecular weight 288.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.35 mL	34.70 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.74 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CP 93129 dihydrochloride

References are publications that support the biological activity of the product.

Hamid Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 2014 PMID: 24381287
Lee Infusion of the serotonin_1B (5-HT_1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 1998 PMID: 9566817
Koe Biochemical and behavioral studies of the 5-HT_1B receptor agonist, CP-94,253. Drug Development Research

Citations for CP 93129 dihydrochloride (9)

Showing 1 - 9 of 9 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for CP 93129 dihydrochloride include:

Zhou et al. (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res. 356:148
PMID: 29949735
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 118:79
PMID: 28300552
Medrihan et al. (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 95:564
PMID: 28735749
Majeed et al. (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016:7291438
PMID: 26989517
Watts et al. (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex. 3:e00103
PMID: 25692021
Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. 165:1390
PMID: 19963045
Watakabe et al. (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron. 19:1915
PMID: 19056862
Heisler et al. (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther. 51:239
PMID: 16846858
Rau et al. (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med. 318:676
PMID: 16687477

There are no citations that match your criteria.

Showing 1 - 9 of 9 citations Showing All

Customer Reviews for CP 93129 dihydrochloride (2)

3.5 out of 5

2 customer ratings

5 stars

4 stars

50%

3 stars

50%

2 stars

1 star

Customer Images

Showing 1 - 2 of 2 reviews Showing All

Filter By:

5-HT has a potential for relaxant

Name: Anonymous

Species: Rat

Assay Type: In Vivo

CP93129 (5-HT1B)10nM

PMID: 25692021
Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

CP (10mM)

PMID: 28735749

There are no reviews that match your criteria.

Showing 1 - 2 of 2 reviews Showing All

Product Documents for CP 93129 dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.