CP 809101 hydrochloride

Name: CP 809101 hydrochloride
Brand: Tocris Bioscience
SKU: 3041

Catalog # 3041 | Tocris Bioscience a Bio-Techne Brand

Citations (5)

COA / SDS

Potent and selective 5-HT2C agonist

Key Product Details

Description:	Potent and selective 5-HT_2C agonist
Chemical Name:	2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	341.24

View Full Technical Details for CP 809101 hydrochloride

Technical Data
Citations (5) / Reviews

Biological Activity for CP 809101 hydrochloride

CP 809101 hydrochloride is a potent and selective 5-HT_2C receptor agonist (pEC₅₀ values are 9.96, 7.19 and 6.81 for human 5-HT_2C, 5-HT_2B and 5-HT_2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.

Compound Libraries for CP 809101 hydrochloride

CP 809101 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 809101 hydrochloride

M. Wt	341.24
Formula	C₁₅H₁₇N₄OCl.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1215721-40-6
PubChem ID	56972220
InChi Key	NMUNRTCTDLORDR-UHFFFAOYSA-N
Smiles	ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 809101 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.82	20
	DMSO	34.12	100

Preparing Stock Solutions for CP 809101 hydrochloride

The following data is based on the product molecular weight 341.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.65 mL	29.30 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for CP 809101 hydrochloride

References are publications that support the biological activity of the product.

Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem 2013 PMID: 23301527
Siuciak CP-809,101, a selective 5-HT_2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology 2007 PMID: 16949622
Kalgutkar Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine_2c receptor agonist for the treatment of obesity: role of metabolic activation. Drug Metab.Dispos. 2007 PMID: 17344339

Citations for CP 809101 hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CP 809101 hydrochloride include:

Yamamoto (2017) Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice. Neuropharmacology. 112:188
PMID: 27480795
Gerhold et al. (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 35:9580
PMID: 26134641
Goda et al. (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 228:271
PMID: 23525524
Schulz et al. (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 167:1480
PMID: 22817643
Austgen et al. (2012) 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii. Oncotarget. 108:2292
PMID: 22855775

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