CP 673451

Name: CP 673451
Brand: Tocris Bioscience
SKU: 5993

Tocris Bioscience, part of Bio-Techne | Catalog # 5993

Citations (11)

COA / SDS

Potent and selective PDGFR inhibitor

Key Product Details

Description:	Potent and selective PDGFR inhibitor
Chemical Name:	1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	417.5

View Full Technical Details for CP 673451

Technical Data
Citations

Biological Activity for CP 673451

CP 673451 is a potent and selective PDGFR inhibitor (IC₅₀ values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

Compound Libraries for CP 673451

CP 673451 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Technical Data for CP 673451

M. Wt	417.5
Formula	C₂₄H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	343787-29-1
PubChem ID	10158940
InChi Key	DEEOXSOLTLIWMG-UHFFFAOYSA-N
Smiles	COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 673451

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.35	20

Preparing Stock Solutions for CP 673451

The following data is based on the product molecular weight 417.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.98 mL	59.88 mL	119.76 mL
1 mM	2.40 mL	11.98 mL	23.95 mL
2 mM	1.20 mL	5.99 mL	11.98 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

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References for CP 673451

References are publications that support the biological activity of the product.

Roberts Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 PMID: 15705896