CP 471474

Name: CP 471474
Brand: Tocris Bioscience
SKU: 3780

Tocris Bioscience, part of Bio-Techne | Catalog # 3780

Citations (4)

COA / SDS

Broad spectrum MMP inhibitor

Discontinued Product

3780 has been discontinued. View all Synthetic Metalloprotease Inhibitors products.

Key Product Details

Description:	Broad spectrum MMP inhibitor
Chemical Name:	2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
Purity:	≥97% (HPLC)
Molecular Weight:	368.38

View Full Technical Details for CP 471474

Technical Data
Citations

Biological Activity for CP 471474

CP 471474 is a broad spectrum MMP inhibitor (IC₅₀ values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 471474

M. Wt	368.38
Formula	C₁₆H₁₇FN₂O₅S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	210755-45-6
PubChem ID	9907286
InChi Key	QCOQJYRPDUMCNP-UHFFFAOYSA-N
Smiles	FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CP 471474

References are publications that support the biological activity of the product.

Lindsey Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 2002 PMID: 11839633
Fang Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 2007 PMID: 17689559
Rohde Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 1999 PMID: 10368126