CP 465022 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2932
Selective and non-competitive AMPA antagonist
Key Product Details
Description
Selective and non-competitive AMPA antagonist
Product Description
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.Product Specifications
Molecular Weight
499.41
Formula
C26H24ClFN4O.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
CAS Number
1785666-59-2
PubChem ID
53251536
InChI Key
YKYDGCRJPYLXHY-GVYCEHEKSA-N
SMILES
O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.94 | 100 |
Preparing Stock Solutions
for CP 465022 hydrochloride
The following data is based on the product molecular weight 499.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Menniti CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 2003 PMID: 12511770
- Welch Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 2008 PMID: 18687344
- Lazaro Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 2002 PMID: 11804610
Product Specific Notices for CP 465022 hydrochloride
For research use only
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