CP 43
Tocris Bioscience, part of Bio-Techne | Catalog # 6558
Potent TAOK inhibitor
Product Description
CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.Product Specifications
Molecular Weight
384.47
Formula
C25H24N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
CAS Number
850467-66-2
PubChem ID
46673962
InChI Key
WQKXOAJVNFOHNZ-UHFFFAOYSA-N
SMILES
O=C(NC1CCCC2=CC=CC=C12)CNC(C3=CC=C(C4=CC=CC=C4)C=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.45 | 100 | |
| Ethanol | 7.69 | 20 |
Preparing Stock Solutions
for CP 43
The following data is based on the product molecular weight 384.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.60 mL | 13.00 mL | 26.01 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.20 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Giacomini A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 2018 PMID: 29730992
- Koo Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 2017 PMID: 28830982
Product Specific Notices for CP 43
For research use only
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