CP 316819
Tocris Bioscience, part of Bio-Techne | Catalog # 3542
Selective glycogen phosphorylase inhibitor
Key Product Details
Description
Selective glycogen phosphorylase inhibitor
Product Description
CP 316819 is a selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.Product Specifications
Molecular Weight
415.87
Formula
C21H22ClN3O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
CAS Number
186392-43-8
PubChem ID
10273347
InChI Key
WEQLRDLTRCEUHG-PKOBYXMFSA-N
SMILES
O=C(N[C@@H](CC3=CC=CC=C3)[C@H](C(N(OC)C)=O)O)C2=CC1=CC(Cl)=CC=C1N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.59 | 100 | |
| Ethanol | 41.59 | 100 |
Preparing Stock Solutions
for CP 316819
The following data is based on the product molecular weight 415.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 12.02 mL | 24.05 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.81 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Freeman Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation site of the enzyme. Br.J.Pharmacol. 2006 PMID: 17016495
- Suh Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-ca J.Pharmacol.Exp.Ther. 2007 PMID: 17251391
- Baker Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes 2005 PMID: 16046314
Product Specific Notices for CP 316819
For research use only
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