Corticosterone

Name: Corticosterone
Brand: Tocris Bioscience
SKU: 3685
Rating: 5 (1 reviews)

Catalog # 3685 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (4)

COA / SDS

Endogenous glucocorticoid

Key Product Details

Description:	Endogenous glucocorticoid
Chemical Name:	(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Purity:	≥99% (HPLC)
Molecular Weight:	346.46

View Full Technical Details for Corticosterone

Technical Data
Citations (4) / Reviews (1)

Biological Activity for Corticosterone

Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Compound Libraries for Corticosterone

Corticosterone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Corticosterone

M. Wt	346.46
Formula	C₂₁H₃₀O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	50-22-6
PubChem ID	5753
InChi Key	OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Smiles	[H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Corticosterone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.65	100

Preparing Stock Solutions for Corticosterone

The following data is based on the product molecular weight 346.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.43 mL	28.86 mL
5 mM	0.58 mL	2.89 mL	5.77 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Molarity Calculator

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Reconstitution Calculator

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References for Corticosterone

References are publications that support the biological activity of the product.

Lu International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 2006 PMID: 17132855

Citations for Corticosterone (4)

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Citations are publications that use Bio-Techne products. Selected citations for Corticosterone include:

Gang et al. (2021) Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. J Neurochem. 158:358-372
PMID: 33025573
Ahmad et al. (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol. 39:188
PMID: 30567483
Roshanak et al. (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife. 8
PMID: 31433293
Shikatani et al. (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One. 7:e46625
PMID: 23056375

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Customer Reviews for Corticosterone (1)

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Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: rat adrenal medulla chromaffin cells

1 mM

PMID: 30567483

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