CORM 3
Tocris Bioscience, part of Bio-Techne | Catalog # 5320
Water-soluble carbon monoxide-releasing molecule
Key Product Details
Description
Water-soluble carbon monoxide-releasing molecule
Alternative Names
Carbon monoxide releasing molecule 3
Product Description
CORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.Product Specifications
Molecular Weight
294.61
Formula
C5H4ClNO5Ru
Storage
Store at -20°C
Chemical Name
Tricarbonylchloro(glycinato)ruthenium
CAS Number
475473-26-8
PubChem ID
9817618
InChI Key
IMFIZOFAMSDJSP-UHFFFAOYSA-L
SMILES
[Cl-][Ru++]1([NH2]CC(=O)[O-]1)(C#[O])(C#[O])C#[O]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.46 | 100 |
Preparing Stock Solutions
for CORM 3
The following data is based on the product molecular weight 294.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.39 mL | 16.97 mL | 33.94 mL |
| 5 mM | 0.68 mL | 3.39 mL | 6.79 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.39 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sawle Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 2005 PMID: 15880142
- Foresti Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 2004 PMID: 15148243
- Filippo Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 2012 PMID: 22038495
- Clark Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 2003 PMID: 12842916
- Bani-Hani Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 2006 PMID: 16772536
Product Specific Notices for CORM 3
For research use only
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