Conduritol B epoxide

Product Description

Conduritol B epoxide is an irreversible glucocerebrosidase (GBA) inhibitor (K_i = 53 μM; IC₅₀ = 4.28 - 9.49 μM). Also inhibitis lysosomal α-glucosidase. Used to generate animal models of Gaucher disease. Accelerates recovery of peripheral nerve injury in mice. Preserves motoneurons and ganglioside distribution at the neuromuscular junction, delays disease onset and improves motor function in a mouse ALS model.

Solubility

Preparing Stock Solutions for Conduritol B epoxide

The following data is based on the product molecular weight 162.14

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.84 mL	61.68 mL
5 mM	1.23 mL	6.17 mL	12.34 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kuo In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. FEBS J. 2019 PMID: 30600575
• Henriques Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of Amyotrophic Lateral Sclerosis. Sci.Rep. 2017 PMID: 28701774
• Artola Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. J.Am.Chem.Soc. 2019 PMID: 30811188
• Witte Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat.Chem.Biol. 2010 PMID: 21079602