Colchicine
Tocris Bioscience, part of Bio-Techne | Catalog # 1364
Inhibitor of tubulin
Product Description
Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.Product Specifications
Molecular Weight
399.44
Formula
C22H25NO6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
CAS Number
64-86-8
PubChem ID
2833
InChI Key
IAKHMKGGTNLKSZ-UHFFFAOYSA-N
SMILES
COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.94 | 100 | |
| DMSO | 39.94 | 100 |
Preparing Stock Solutions
for Colchicine
The following data is based on the product molecular weight 399.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.52 mL | 25.04 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Martinez The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation. Atherosclerosis 2018 PMID: 29352570
- Ribeiro The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabol.Open 2020 PMID: 32808940
- Morselli Network medicine framework for identifying drug repurposing opportunities for COVID-19. Proc.Nat.Acad.Sci.U.S.A. 2021 PMID: 33906951
- Hastie Interactions of colch. with tubulin. Pharmacol.Ther. 1991 PMID: 1792241
- Burns Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 1992 PMID: 1544399
- Bai Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 1996 PMID: 8647876
Product Specific Notices for Colchicine
For research use only
⚠ WARNING: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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