Key Product Details
Description: | Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist |
Chemical Name: | 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 326.83 |
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Citations for Clozapine (20)
Citations are publications that use Bio-Techne products. Selected citations for Clozapine include:
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Maldonado et al.
(2021)
Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons.
Curr Biol.
31:322
PMID: 33157028 -
Dong et al.
(2020)
A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance
Neurobiol Stress.
13
PMID: 33344719 -
Joshi and Panicker
(2019)
Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
Eneuro.
5
PMID: 30713996 -
Peng et al.
(2018)
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell.
172:719
PMID: 29398112 -
Griebel et al.
(2016)
The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits intranslational models of cognitive symptoms associated with schizophrenia
Scientific Reports.
6:35320
PMID: 27734956 -
Cui et al.
(2016)
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits.
Mol Brain.
9:89
PMID: 27729083 -
Canfrán-Duque et al.
(2015)
Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
Int J Tryptophan Res.
10:e0141829
PMID: 26517556 -
Larsson et al.
(2015)
Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.
Brain Res.
8:49
PMID: 26448689 -
Jia et al.
(2013)
Age-dependent regulation of synaptic connections by DA D2 receptors.
Nat Neurosci.
16:1627
PMID: 24121738 -
Chau et al.
(2013)
Pramipexole reduces phosphorylation of α-synuclein at serine-129.
Exp Mol Med.
51:573
PMID: 23681749 -
Kurita et al.
(2012)
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Nat Neurosci.
15:1245
PMID: 22864611 -
Herwerth et al.
(2012)
D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1.
Cereb Cortex.
22:1786
PMID: 21955919 -
Hillenmeyer et al.
(2010)
Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.
Genome Biol.
11:R30
PMID: 20226027 -
Magliaro and Saldanha
(2009)
Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
Brain Res.
1283:14
PMID: 19501068 -
Oliver and Davies
(2009)
Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.
Hum Mol Genet.
18:4576
PMID: 19729413 -
Singh et al.
(2009)
Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, cloz. and MDL 100907.
Int J Neuropsychopharmacol.
12:651
PMID: 18976543 -
Balu et al.
(2008)
Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
J Mol Neurosci.
1211:37
PMID: 18433734 -
Roh et al.
(2007)
Haloperidol and cloz. differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex.
Front Cell Neurosci.
39:353
PMID: 17603289 -
Hampson et al.
(2007)
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Diabetologia.
50:1743
PMID: 17579833 -
Sur et al.
(2003)
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity.
Proc Natl Acad Sci U S A.
100:13674
PMID: 14595031
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