Clotrimazole

Name: Clotrimazole
Brand: Tocris Bioscience
SKU: 4096

Tocris Bioscience, part of Bio-Techne | Catalog # 4096

Citations (28)

COA / SDS

Cytochrome P450 inhibitor; antifungal

Key Product Details

Description:	Cytochrome P450 inhibitor; antifungal
Alternative Names:	CLT
Chemical Name:	1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Purity:	≥98% (HPLC)
Molecular Weight:	344.84

View Full Technical Details for Clotrimazole

Technical Data
Citations

Biological Activity for Clotrimazole

Clotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca²⁺-activated K⁺ current (IC₅₀ = 3 μM) and L-type Ca²⁺ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).

Compound Libraries for Clotrimazole

Clotrimazole is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Clotrimazole

M. Wt	344.84
Formula	C₂₂H₁₇ClN₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	23593-75-1
PubChem ID	2812
InChi Key	VNFPBHJOKIVQEB-UHFFFAOYSA-N
Smiles	ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clotrimazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.86	75
	ethanol	34.48	100

Preparing Stock Solutions for Clotrimazole

The following data is based on the product molecular weight 344.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.50 mL	29.00 mL
5 mM	0.58 mL	2.90 mL	5.80 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for Clotrimazole

References are publications that support the biological activity of the product.

Lempiainen Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 2005 PMID: 15905360
Wu Inhibition of Ca²⁺-activated K⁺ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 1999 PMID: 10428416
Thomas The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 1999 PMID: 10323582
Snajdrova Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 1998 PMID: 9774419