CITCO

Name: CITCO
Brand: Tocris Bioscience
SKU: 3683

Tocris Bioscience a Bio-Techne Brand

Catalog # 3683

Citations (3)

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Key Product Details

Description:	Selective CAR agonist
Chemical Name:	6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
Purity:	≥98% (HPLC)
Molecular Weight:	436.74

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Biological Activity for CITCO

CITCO is a constitutive androstane receptor (CAR) agonist (EC₅₀ = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.

Compound Libraries for CITCO

CITCO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CITCO

M. Wt	436.74
Formula	C₁₉H₁₂Cl₃N₃OS
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	338404-52-7
PubChem ID	9600409
InChi Key	ZQWBOKJVVYNKTL-AUEPDCJTSA-N
Smiles	ClC(C(Cl)=C4)=CC=C4CO/N=C/C1=C(C3=CC=C(Cl)C=C3)N=C2N1C=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CITCO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.84	50

Preparing Stock Solutions for CITCO

The following data is based on the product molecular weight 436.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.58 mL	22.90 mL	45.79 mL
2.5 mM	0.92 mL	4.58 mL	9.16 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

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References for CITCO

References are publications that support the biological activity of the product.

Clen A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3. J.Pharmacol.Exp.Ther. 2009 PMID: 19820207
Moreau Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem.Biophys.Res.Comm. 2007 PMID: 17585873
Maglich Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J.Biol.Chem. 2003 PMID: 12611900

Citations for CITCO (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CITCO include:

McMahon et al. (2019) Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes. Mol Pharmacol. 95:97
PMID: 30361333
Cherian et al. (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 87:878
PMID: 25762023
Yueh et al. (2012) Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 7:e37705
PMID: 22761658

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