Cisapride

Name: Cisapride
Brand: Tocris Bioscience
SKU: 1695

Catalog # 1695 | Tocris Bioscience a Bio-Techne Brand

Citations (4)

COA / SDS

5-HT4 agonist; stimulates intestinal ACh release

Key Product Details

Description:	5-HT₄ agonist; stimulates intestinal ACh release
Alternative Names:	R 51619
Chemical Name:	(±)-4-Amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	465.95

View Full Technical Details for Cisapride

Technical Data
Citations (4) / Reviews

Biological Activity for Cisapride

Cisapride is a 5-HT₄ receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT₄ receptor-dependent and -independent mechanisms, leading to increased intestinal motility.

Compound Libraries for Cisapride

Cisapride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Cisapride

M. Wt	465.95
Formula	C₂₃H₂₉ClFN₃O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	81098-60-4
PubChem ID	6917698
InChi Key	VTMCXFGKGQNNBD-IWONEHLMSA-N
Smiles	CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1.CO[C@@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cisapride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.59	100

Preparing Stock Solutions for Cisapride

The following data is based on the product molecular weight 465.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for Cisapride

References are publications that support the biological activity of the product.

Briejer Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine₄ (5-HT₄) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8321323
Taniyama Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 1991 PMID: 1890614
Schuurkes Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 1985 PMID: 3897516

Citations for Cisapride (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Cisapride include:

Padayatti et al. (2013) A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 12:1259
PMID: 23378516
Beattie et al. (2011) The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2:25
PMID: 21687517
Murray et al. (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 106:925
PMID: 21653728
Xiang et al. (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol. 93:1145
PMID: 15738272

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