Cisapride
Tocris Bioscience, part of Bio-Techne | Catalog # 1695
5-HT4 agonist; stimulates intestinal ACh release
Key Product Details
Description
5-HT4 agonist; stimulates intestinal ACh release
Alternative Names
R 51619
Product Description
Cisapride is a 5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.Product Specifications
Molecular Weight
465.95
Formula
C23H29ClFN3O4
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
(±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
CAS Number
81098-60-4
PubChem ID
6917698
InChI Key
VTMCXFGKGQNNBD-IWONEHLMSA-N
SMILES
CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1.CO[C@@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.59 | 100 |
Preparing Stock Solutions
for Cisapride
The following data is based on the product molecular weight 465.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.73 mL | 21.46 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.29 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schuurkes Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 1985 PMID: 3897516
- Taniyama Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 1991 PMID: 1890614
- Briejer Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8321323
Product Specific Notices for Cisapride
For research use only
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