cis-22a

Name: cis-22a
Brand: Tocris Bioscience
SKU: 7118

Tocris Bioscience a Bio-Techne Brand

Catalog # 7118

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Key Product Details

Description:	TRPV6 inhibitor
Chemical Name:	1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine ditrifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	563.54

View Full Technical Details for cis-22a

Biological Activity for cis-22a

cis-22a is a TRPV6 inhibitor (IC₅₀ = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Compound Libraries for cis-22a

cis-22a is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for cis-22a

M. Wt	563.54
Formula	C₂₂H₂₉N₃.2CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1819366-84-1
InChi Key	UMKPISXYUQWXJJ-XWOHEVPJSA-N
Smiles	CC1=CC=CC([C@@H]2CC[C@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis-22a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	56.35	100
	DMSO	56.35	100

Preparing Stock Solutions for cis-22a

The following data is based on the product molecular weight 563.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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Reconstitution Calculator

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References for cis-22a

References are publications that support the biological activity of the product.

Cunha Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 2019 PMID: 31531207
Simonin Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 2015 PMID: 26457814

Citations for cis-22a

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