CI 994

Name: CI 994
Brand: Tocris Bioscience
SKU: 2952
Price: 185 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2952

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Key Product Details

Description:	Class I histone deacetylase inhibitor; orally active
Alternative Names:	N-acetyldinaline
Chemical Name:	4-(Acetylamino)-N-(2-aminophenyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	269.3

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Biological Activity for CI 994

CI 994 is an orally active class I histone deacetylase (HDAC) inhibitor (K_i values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G₁ cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Also increases efficiency of hepatic differentiation of hPSCs

Compound Libraries for CI 994

CI 994 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CI 994

M. Wt	269.3
Formula	C₁₅H₁₅N₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	112522-64-2
PubChem ID	2746
InChi Key	VAZAPHZUAVEOMC-UHFFFAOYSA-N
Smiles	O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CI 994

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.93	100

Preparing Stock Solutions for CI 994

The following data is based on the product molecular weight 269.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.57 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for CI 994

References are publications that support the biological activity of the product.

Gräff Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 2014 PMID: 24439381
Beckers Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 2007 PMID: 17455259
Kraker Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2003 PMID: 12700284

Citations for CI 994

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