CI 988
Tocris Bioscience, part of Bio-Techne | Catalog # 2607
Potent and selective CCK2 antagonist
Key Product Details
Description
Potent and selective CCK2 antagonist
Alternative Names
PD 134308
Product Description
CI 988 is a potent and selective CCK2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors (IC50 values are 1.7 and 2717 nM for CCK2 and CCK1 respectively). Has negligible affinity at a range of other binding sites (IC50 > 10 μM). Exhibits anxiolytic activity following oral administration.Product Specifications
Molecular Weight
614.73
Formula
C35H42N4O6
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
CAS Number
130332-27-3
PubChem ID
108187
InChI Key
FVQSSYMRZKLFDR-ZABPBAJSSA-N
SMILES
C[C@](NC(OC5C3CC(CC5C6)CC6C3)=O)(C(NC[C@@H]([C@]4=CC=CC=C4)NC(CCC(O)=O)=O)=O)CC2=CNC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.47 | 100 |
Preparing Stock Solutions
for CI 988
The following data is based on the product molecular weight 614.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Andre Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies. J.Neurosci. 2005 PMID: 16135746
- Hughes Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA
- Moody CI-988 inhibits growth of small cell lung cancer cells. J.Pharmacol.Exp.Ther. 2001 PMID: 11714907
Product Specific Notices for CI 988
For research use only
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