CI 976

Tocris Bioscience, part of Bio-Techne | Catalog # 2227

Selective ACAT inhibitor
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Key Product Details

Description

Selective ACAT inhibitor

View all Acyl-CoA:Cholesterol Acyltransferase Inhibitors »

Product Description

CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).

Product Specifications

Molecular Weight

393.57

Formula

C23H39NO4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

CAS Number

114289-47-3

PubChem ID

122327

InChI Key

WAFNZAURAWBNDZ-UHFFFAOYSA-N

SMILES

CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.36 100
Ethanol 19.68 50

Preparing Stock Solutions for CI 976

The following data is based on the product molecular weight 393.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.70 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for CI 976

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CI 976

For research use only

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