CHS 828

Name: CHS 828
Brand: Tocris Bioscience
SKU: 6753

Tocris Bioscience, part of Bio-Techne | Catalog # 6753

Citations (2)

COA / SDS

NAMPT inhibitor; active in vivo and cytotoxic

Key Product Details

Description:	NAMPT inhibitor; active in vivo and cytotoxic
Chemical Name:	N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
Purity:	≥98% (HPLC)
Molecular Weight:	371.86

View Full Technical Details for CHS 828

Technical Data
Citations

Biological Activity for CHS 828

CHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD⁺. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.

Compound Libraries for CHS 828

CHS 828 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHS 828

M. Wt	371.86
Formula	C₁₉H₂₂ClN₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	200484-11-3
PubChem ID	148198
InChi Key	BOIPLTNGIAPDBY-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C=C1)OCCCCCCN/C(NC#N)=N/C2=CC=NC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHS 828

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.19	100

Preparing Stock Solutions for CHS 828

The following data is based on the product molecular weight 371.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for CHS 828

References are publications that support the biological activity of the product.

Karpov Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 2018 PMID: 30128077
Olesen Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 2008 PMID: 18201551
Hjarnaa CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 1999 PMID: 10582695