CHR 6494 trifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 5326
Potent and selective haspin inhibitor
Product Description
CHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.Product Specifications
Molecular Weight
406.36
Formula
C16H16N6.CF3CO2H
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate
CAS Number
1458630-17-5
PubChem ID
91691123
InChI Key
ILWYDZNXJQESDI-UHFFFAOYSA-N
SMILES
CCCNC2=NN1C(C3=CC(C=NN4)=C4C=C3)=CN=C1C=C2.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.64 | 100 |
Preparing Stock Solutions
for CHR 6494 trifluoroacetate
The following data is based on the product molecular weight 406.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.30 mL | 24.61 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huertas Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 2012 PMID: 21804608
Product Specific Notices for CHR 6494 trifluoroacetate
For research use only
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