CHPG

Tocris Bioscience, part of Bio-Techne | Catalog # 1049

(1)

Citations (102)

COA / SDS

mGlu5 selective agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

mGlu5 selective agonist

View all Group I mGluR Agonists »

Product Description

CHPG is a selective mGlu₅ metabotropic glutamate receptor agonist, completely inactive at mGlu_1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Product Specifications

Molecular Weight

201.61

Formula

C₈H₈NO₃Cl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

(RS)-2-Chloro-5-hydroxyphenylglycine

CAS Number

170846-74-9

PubChem ID

3645780

InChI Key

UNIDAFCQFPGYJJ-UHFFFAOYSA-N

SMILES

NC(C(O)=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	20.16	100

Preparing Stock Solutions for CHPG

The following data is based on the product molecular weight 201.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.96 mL	24.80 mL	49.60 mL
5 mM	0.99 mL	4.96 mL	9.92 mL
10 mM	0.50 mL	2.48 mL	4.96 mL
50 mM	0.10 mL	0.50 mL	0.99 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Ugolini Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones. Neuropharmacology 1999 PMID: 10530818
Doherty (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997 PMID: 9144665
Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
Bao Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 2001 PMID: 11743947