CHPG

Name: CHPG
Brand: Tocris Bioscience
SKU: 1049

Tocris Bioscience a Bio-Techne Brand

Catalog # 1049

Citations (17)

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Key Product Details

Description:	mGlu₅ selective agonist
Chemical Name:	(RS)-2-Chloro-5-hydroxyphenylglycine
Purity:	≥99% (HPLC)
Molecular Weight:	201.61

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Biological Activity for CHPG

CHPG is a selective mGlu₅ metabotropic glutamate receptor agonist, completely inactive at mGlu_1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Technical Data for CHPG

M. Wt	201.61
Formula	C₈H₈NO₃Cl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170846-74-9
PubChem ID	3645780
InChi Key	UNIDAFCQFPGYJJ-UHFFFAOYSA-N
Smiles	NC(C(O)=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	20.16	100

Preparing Stock Solutions for CHPG

The following data is based on the product molecular weight 201.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.96 mL	24.80 mL	49.60 mL
5 mM	0.99 mL	4.96 mL	9.92 mL
10 mM	0.50 mL	2.48 mL	4.96 mL
50 mM	0.10 mL	0.50 mL	0.99 mL

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References for CHPG

References are publications that support the biological activity of the product.

Bao Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 2001 PMID: 11743947
Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
Ugolini Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones. Neuropharmacology 1999 PMID: 10530818
Doherty (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997 PMID: 9144665

Citations for CHPG (17)

Showing 1 - 10 of 17 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CHPG include:

David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience. 349:341
PMID: 28300633
Tang et al. (2015) Stimulation-evoked Ca²⁺ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 35:3016
PMID: 25698739
Loane et al. (2013) Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Biol Chem. 30:403
PMID: 23199080
Rojas et al. (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 83:106
PMID: 23066089
Hino et al. (2012) Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children. PLoS One. 7:e42920
PMID: 22916181
Kammermeier (2012) The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency. Proc Natl Acad Sci U S A. 12:6
PMID: 22642439
Beard et al. (2012) Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine. Vascul Pharmacol. 56:159
PMID: 22285407
Ren et al. (2012) Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 116:122
PMID: 22123524
Liu et al. (2012) Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 9:258
PMID: 23181395
Chen et al. (2011) mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci. 18:19
PMID: 21342491
Parri et al. (2010) Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. Eur J Neurosci. 32:29
PMID: 20608967
Lin et al. (2009) Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. J Biomed Sci. 16:94
PMID: 19832997
Byrnes et al. (2009) Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 66:63
PMID: 19670441
Byrnes et al. (2009) Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. J Neurotrauma. 57:550
PMID: 18816644
Neyman and Manahan-Vaughan (2008) Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. Eur J Neurosci. 27:1345
PMID: 18364018
Kim et al. (2008) Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome. BMC Pharmacol. 105:4429
PMID: 18332424
Ferré et al. (2002) Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Glia. 99:11940
PMID: 12189203

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