Key Product Details
Description: | mGlu5 selective agonist |
Chemical Name: | (RS)-2-Chloro-5-hydroxyphenylglycine |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 201.61 |
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Citations for CHPG (17)
Citations are publications that use Bio-Techne products. Selected citations for CHPG include:
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David-Pereira
(2017)
The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
Neuroscience.
349:341
PMID: 28300633 -
Tang et al.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
J Neurosci.
35:3016
PMID: 25698739 -
Loane et al.
(2013)
Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.
J Biol Chem.
30:403
PMID: 23199080 -
Rojas et al.
(2013)
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Mol Pharmacol.
83:106
PMID: 23066089 -
Hino et al.
(2012)
Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
PLoS One.
7:e42920
PMID: 22916181 -
Kammermeier
(2012)
The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency.
Proc Natl Acad Sci U S A.
12:6
PMID: 22642439 -
Beard et al.
(2012)
Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
Vascul Pharmacol.
56:159
PMID: 22285407 -
Ren et al.
(2012)
Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
Anesthesiology.
116:122
PMID: 22123524 -
Liu et al.
(2012)
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
J Neuroinflammation.
9:258
PMID: 23181395 -
Chen et al.
(2011)
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
J Biomed Sci.
18:19
PMID: 21342491 -
Parri et al.
(2010)
Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
Eur J Neurosci.
32:29
PMID: 20608967 -
Lin et al.
(2009)
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
J Biomed Sci.
16:94
PMID: 19832997 -
Byrnes et al.
(2009)
Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.
Ann Neurol.
66:63
PMID: 19670441 -
Byrnes et al.
(2009)
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
J Neurotrauma.
57:550
PMID: 18816644 -
Neyman and Manahan-Vaughan
(2008)
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Eur J Neurosci.
27:1345
PMID: 18364018 -
Kim et al.
(2008)
Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
BMC Pharmacol.
105:4429
PMID: 18332424 -
Ferré et al.
(2002)
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
Glia.
99:11940
PMID: 12189203
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